Cell cycle control of DNA replication.

B Stillman

doi:10.1126/science.274.5293.1659

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Cell cycle control of DNA replication.

B Stillman

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Abstract

The initiation of DNA replication in eukaryotic cells is a highly regulated process that leads to the duplication of the genetic information for the next cell generation. This requires the ordered assembly of many proteins at the origins of DNA replication to form a competent, pre-replicative chromosomal state. In addition to this competent complex, at least two cell cycle regulated protein kinase pathways are required to affect a transition to a post-replicative chromosomal state. Protein kinases required to establish mitosis prevent re-replication of the DNA. As cells exit mitosis, the cell cycle is reset, allowing the establishment of a new, competent replication state.

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Animals Cell Cycle Cell Cycle Proteins Chromosomes Cyclin-Dependent Kinases Cyclins DNA Replication Fungal Proteins Mitosis Protein Kinases Protein Serine-Threonine Kinases Replication Origin S Phase Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Schizosaccharomyces pombe Proteins Journal Article Research Support, U.S. Gov't, P.H.S.Review

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B Stillman. 1996-12-06. Cell cycle control of DNA replication.. https://doi.org/10.1126/science.274.5293.1659

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