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PubMed · 8939849

Cancer cell cycles.

C J Sherr
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Abstract

Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16(INK4a) and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein (RB) and control exit from the G1 phase of the cell cycle, are so frequent in human cancers that inactivation of this pathway may well be necessary for tumor development. Like the tumor suppressor protein p53, components of this "RB pathway," although not essential for the cell cycle per se, may participate in checkpoint functions that regulate homeostatic tissue renewal throughout life.

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AnimalsCarrier ProteinsCell CycleCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent KinasesCyclinsG1 PhaseGene Expression Regulation, NeoplasticGenes, Tumor SuppressorHumansNeoplasmsProto-OncogenesRetinoblastoma ProteinS PhaseSignal TransductionTumor Suppressor Protein p53Journal ArticleResearch Support, Non-U.S. Gov'tReview

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C J Sherr. 1996-12-06. Cancer cell cycles.. https://doi.org/10.1126/science.274.5293.1672

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