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PubMed · 8946921

Thymic and extrathymic T cell development.

G Leclercq·J Plum
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Abstract

The majority of T cells located in peripheral blood, spleen and lymph nodes are dependent on the thymus for proper differentiation and function. Only a minority of T lymphocytes located in these lymphoid organs is thymic-independent. In contrast, a large number of thymus-independent T cells is present in the gut epithelium. This review deals with phenotypic and functional characteristics of T cell development, summarizes the knowledge on the cytokine requirement in this process and describes positive and negative selection. The differences between thymic-dependent and thymic-independent T cells are emphasized, including selection processes, CD4-CD8 expression and the composition of the CD3 complex.

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AnimalsHumansT-LymphocytesThymus GlandJournal ArticleResearch Support, Non-U.S. Gov'tReview

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G Leclercq, J Plum. 1996. Thymic and extrathymic T cell development.. https://pubmed.ncbi.nlm.nih.gov/8946921/

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