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PubMed · 8950955

[Development of beta 2-selective, long-acting agonists].

N Inagaki·H Nagai
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Abstract

beta 2-Agonists have been the main bronchodilator drugs used in the symptomatic treatment of asthma. Regular use of beta 2-agonists, however, is well known to produce tolerance to their bronchoprotective effect. It has been pointed out that the over-treatment with beta 2-agonists may be associated with worsening asthma and increased risk of life-threatening attacks. To reduce the cardiovascular side effects, compounds with advanced beta 2-selectivity have been examined and established. Newly developed beta 2-selective agonists are structurally stable and long-acting. Some of them are reported to be effective for treatment of late asthmatic response, although conventional beta-agonists are thought to be relatively ineffective.

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Adrenergic beta-AgonistsAnimalsAnti-Allergic AgentsAsthmaDelayed-Action PreparationsDrug DesignDrug StabilityHumansImmunoglobulin EReceptors, Adrenergic, betaEnglish AbstractJournal ArticleReview

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N Inagaki, H Nagai. 1996. [Development of beta 2-selective, long-acting agonists].. https://pubmed.ncbi.nlm.nih.gov/8950955/

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