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Sequence and evolution of the human germline V lambda repertoire.

S C Williams·J P Frippiat·I M Tomlinson·O Ignatovich·M P Lefranc·G Winter
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Abstract

We recently completed a map of the human immunoglobulin lambda (IGL) locus on chromosome 22q11.2 and showed that the V lambda genes are arranged in three distinct clusters, each containing members of different V lambda families. We have now sequenced each of these V lambda genes and determined which are functional by comparison with the expressed repertoire. Our analysis indicates that there are approximately 30 functional V lambda genes, depending on the haplotype, that belong to ten V lambda families (five V lambda 1, five V lambda 2, eight V lambda 3, three V lambda 4, three V lambda 5, one V lambda 6, two V lambda 7, one V lambda 8, one V lambda 9 and one V lambda 10). V lambda genes related to the major human V lambda families (V lambda 1, V lambda 2 and V lambda 3) predominate in species that express mainly lambda light chains.

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Amino Acid SequenceBase SequenceDNAEvolution, MolecularGerm CellsHumansImmunoglobulin Variable RegionImmunoglobulin lambda-ChainsMolecular Sequence DataPhylogenySequence Homology, Amino AcidSequence Homology, Nucleic AcidJournal ArticleResearch Support, Non-U.S. Gov't

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S C Williams, J P Frippiat, I M Tomlinson, O Ignatovich, M P Lefranc, G Winter. 1996-11-29. Sequence and evolution of the human germline V lambda repertoire.. https://doi.org/10.1006/jmbi.1996.0636

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