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PubMed · 895586

Mutation selection and tumour progression.

T E Wheldon
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Abstract

It is proposed that tumour progression results from the increased mutability of tumour cells and that this mutability leads to the acquisition of a large number of 'neutral' mutations having no significant effects under physiological conditions but capable of lethal expression under different conditions. High temperatures often lead to expression of neutral mutations and this could provide a mechanism for the observed thermosensitivity of tumour cells, and a rational basis for the use of hyperthermia in cancer treatment.

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Hot TemperatureHumansModels, BiologicalMutationNeoplasm ProteinsNeoplasmsNeoplasms, ExperimentalProtein DenaturationSelection, GeneticJournal Article

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T E Wheldon. Mutation selection and tumour progression.. https://doi.org/10.1016/0306-9877(77)90020-2

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