Sequentially folded SV-11 RNA: metastability is relevant to biological function.

A Fernández; A Belinky

doi:10.1016/s0301-4622(96)02189-8

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PubMed · 8956484

Sequentially folded SV-11 RNA: metastability is relevant to biological function.

A Fernández·A Belinky

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Abstract

By simulating a Markov process comprising kinetically controlled elementary chain-growth steps and upstream refolding events, we compute the sequential folding of SV-11 RNA; a species capable of acting as a template instructing its own replication when folded into a metastable conformation. The predicted structure is endowed with available primers for replication and is identical within the regions of homology to the experimentally probed active structure of MNV-11 RNA, a species from which SV-11 RNA has evolved. The uneven rate of chain growth during SV-11 RNA replication and the pause sites along the replica sequence are determined. Such predictions are testable in pulse-chase kinetic experiments.

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Base Sequence Kinetics Molecular Sequence Data Nucleic Acid Conformation RNA Thermodynamics Journal Article Research Support, Non-U.S. Gov't

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A Fernández, A Belinky. 1996-10-30. Sequentially folded SV-11 RNA: metastability is relevant to biological function.. https://doi.org/10.1016/s0301-4622(96)02189-8

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