Heterotrimeric G-proteins and development.

C C Malbon

doi:10.1016/s0006-2952(96)00662-4

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PubMed · 8960056

Heterotrimeric G-proteins and development.

C C Malbon

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Abstract

Heterotrimeric G-proteins are well-known transducers of signaling from a populous class of heptihelical, membrane receptors to a smaller group of effector molecules that includes adenylylcyclases, cyclic GMP phosphodiesterases, phospholipases (type C beta), and various ion channels. Dramatic changes in specific G-protein subunits that coincide with commitment to highly-specialized cell types suggest a key role for these extrinsic membrane proteins in cell differentiation and development. Through analysis of the effects of gain-of-function and loss-of-function mutants, it has been possible to explore this new dimension in G-protein biology, intimately linking specific G-proteins to development. G-protein subunits are shown to be important molecular switches in the complex biological processes controlling both cellular differentiation and early development.

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Animals Calcium-Calmodulin-Dependent Protein Kinases Cell Differentiation Cell Division GTP-Binding Proteins Humans Journal Article Review

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C C Malbon. 1997-01-10. Heterotrimeric G-proteins and development.. https://doi.org/10.1016/s0006-2952(96)00662-4

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