Immunomodulation by HLA class I-derived peptides.

A M Krensky; C Clayberger

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PubMed · 8962174

Immunomodulation by HLA class I-derived peptides.

A M Krensky·C Clayberger

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Abstract

Synthetic peptides corresponding to linear sequences of HLA class I molecules have profound immunomodulatory effects in vitro and in vivo. Recent clinical trials confirm their potential as the therapeutics for transplantation and for a variety of immune-mediated diseases. These peptides also inhibit NK responses in vivo in humans. The importance of the carboxy end of the alpha 1 alpha helix in negative signaling to both T cells and NK cells focuses attention on new targets for immunotherapy.

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Amino Acid Sequence Animals Clinical Trials as Topic Graft Rejection HLA-A2 Antigen Histocompatibility Antigens Class I Humans Immunotherapy Killer Cells, Natural Peptide Fragments Protein Structure, Secondary Receptors, Antigen, T-Cell T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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A M Krensky, C Clayberger. 1996. Immunomodulation by HLA class I-derived peptides.. https://pubmed.ncbi.nlm.nih.gov/8962174/

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