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PubMed · 8963668

The basal forebrain cholinergic system and object memory in the rat.

N Vnek·L F Kromer·R G Wiley·L A Rothblat
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Abstract

Rats with near complete destruction of basal forebrain cholinergic neurons from intracerebroventricular injections of 192 IgG-saporin were trained on object discrimination problems and then retrained two weeks later to measure retention. Despite dramatic reductions of acetylcholinesterase-positive fibers in hippocampus and neocortex, these animals did not differ from controls on an analysis of savings scores. Thus, the basal forebrain cholinergic system may serve functions that support non-spatial memory but are not specifically mnemonic in nature.

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AcetylcholinesteraseAnimalsAntibodies, MonoclonalCerebral CortexCholinergic AgentsHippocampusImmunotoxinsInjections, IntraventricularMaleMemoryN-Glycosyl HydrolasesNeuronsParasympathetic Nervous SystemProsencephalonRatsRats, WistarRetention, PsychologyRibosome Inactivating Proteins, Type 1SaporinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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N Vnek, L F Kromer, R G Wiley, L A Rothblat. 1996-02-26. The basal forebrain cholinergic system and object memory in the rat.. https://doi.org/10.1016/0006-8993(95)01477-2

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