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Cross-talk between bacterial pathogens and their host cells.

J E Galán·J B Bliska
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Abstract

A taxonomically diverse group of bacterial pathogens have evolved a variety of strategies to subvert host-cellular functions to their advantage. This often involves two-way biochemical interactions leading to responses in both the pathogen and host cell. Central to this interaction is the function of a specialized protein secretion system that directs the export and/or translocation into the host cells of a number of bacterial proteins that can induce or interfere with host-cell signal transduction pathways. The understanding of these bacterial/host-cell interactions will not only lead to novel therapeutic approaches but will also result in a better understanding of a variety of basic aspects of cell physiology and immunology.

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AnimalsBacterial InfectionsBacterial ToxinsCell CommunicationHumansSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

J E Galán, J B Bliska. 1996. Cross-talk between bacterial pathogens and their host cells.. https://doi.org/10.1146/annurev.cellbio.12.1.221

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