PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 8976104

[Hyperuricosuria and urolithiasis].

T Koide
View original source ↗Export metadata ↓

Abstract

Hyperuricosuria with or without hypercalciuria amounted to about 23% of the possible cause of urolithiasis in my clinical experience. Approximately three forth of urolithiasis caused by hyperuricosuria was calcium oxalate stones and the rest was uric acid stones. Uric acid is one of the composition of urinary stones itself, but it has an activity of calcium oxalate stone formation. The hypotheses why the uric acid induced calcium oxalate stones were introduced. The preventive effect of allopurinol on the recurrent calcium oxalate stone formers was proved in our previous study which may revealed the urinary uric acid promoted calcium oxalate stone formation or masked the inhibitory activity of urinary macromolecular inhibitors. On the basis of above statement, I emphasize the importance of the treatment of hyperuricosuria in preventing urinary stones.

Explore related subjects

Calcium OxalateGoutHumansUric AcidUrinary CalculiEnglish AbstractJournal ArticleReview

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

T Koide. 1996. [Hyperuricosuria and urolithiasis].. https://pubmed.ncbi.nlm.nih.gov/8976104/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

The role of Randall's plaques in the pathogenesis of calcium stones.

PURPOSE: Knowledge of the inciting lesion in kidney stone formation has remained rudimentary until quite recently. Randall theorized that areas of apatite plaque on the renal papillae would be an ideal site for an overgrowth of calcium oxalate to develop into a calculus. We reviewed in vivo data that have further defined the role of Randall's plaques in stone disease. MATERIALS AND METHODS: We examined a set of literature that tested 2 hypotheses, that is 1) Randall's plaques are a specialized disease that begins as apatite in a unique region of the kidney due to local driving forces and anatomy, and 2) stones that arise from causes different from common calcium oxalate stones do not necessarily arise on plaque. RESULTS: Intraoperative papillary and cortical biopsy specimens obtained during percutaneous nephrolithotomy from the kidneys of 3 types of stone formers (idiopathic calcium stone formers, patients with stones due to bariatric procedures and brushite stone formers) showed unique histopathological findings. CONCLUSIONS: The metabolic and surgical pathological findings in 3 distinct groups of stone formers demonstrate that the histology of the renal papillae from a stone former is particular to the clinical setting.

Calcium Oxalate↗
PubMed2006

Computation and modeling of the stone-growth related urinary depletion effect using "depletion V1.0".

PURPOSE: During metabolic evaluation stone patients often present with calculi in the urinary tract or are suffering from high frequent formation of small microliths passing routinely the urinary tract. These concrements are presumably in a state of continuous growth. Consequently, the concentrations of the lithogenic components in the voided urine must decrease. Thus, treatment schemes inevitably fail to focus on the true pathogenic urinary composition. Instead, they focus on underestimated concentrations. This can attain high clinical relevance. In recent publications, we introduced a complex physical approach and provided mathematical equations which can be solved analytically. However, to date, solving the equations with a pocket calculator remains cumbersome. MATERIALS AND METHODS: Depletion V1.0 was developed to integrate the calculation of the depletion effect into the daily treatment of stone patients. Minimum requirement for Depletion V1.0 is the Java 1.2 platform runtime environment, which is supported on nearly all operation systems including Linux, MacOS X, and Windows. The program can be used directly within a Java-compliant web browser (e.g. Firefox, Mozilla, Internet Explorer) or from the program's storage location. The implemented data base provides stone type relevant parameters. Data input is performed via an easy-to-handle graphical user interface. RESULTS: Results are given as values and interactive plots; computation and update of plots are performed in real time. Result sheets can be exported to platform-independent EPS-format or printed out directly. CONCLUSIONS: Depletion V1.0 enables the medical practitioner to obtain an improved interpretation of the stone patient's health status. As input, only one set of easy-to-achieve clinical standard parameters is required. The program will be available from the authors as freeware.

Calcium Oxalate↗