Chronic lead intoxication: effects on developing optic nerve.

G Tennekoon; C S Aitchison; J Frangia; D L Price; A M Goldberg

doi:10.1002/ana.410050611

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Chronic lead intoxication: effects on developing optic nerve.

G Tennekoon·C S Aitchison·J Frangia·D L Price·A M Goldberg

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Abstract

The effects of chronic lead intoxication were studied by examining the optic nerve of mice given lead-containing mother's milk from day 1 to day 21 of life. Biochemical assays for myelin basic protein, 2',3'-cyclic nucleotide phosphodieterase, and cerebroside sulfotransferase showed that the total amount of myelin produced by the lead-exposed animals was decreased. Lead exposure did not alter the number of oligodendroglia or the relationship between axons and myelin sheaths. The hypomyelination was paralleled by a reduction in size of optic axons in the lead-exposed animals. The data suggest that chronic exposure to lead in developing mice results in a primary effect on neurons and that hypomyelination is secondary to reduction in axon size.

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2',3'-Cyclic-Nucleotide Phosphodiesterases Age Factors Animals Behavior, Animal Cerebrosides Female Lead Poisoning Maternal-Fetal Exchange Mice Myelin Basic Protein Optic Nerve Organ Size Pregnancy Sulfotransferases Sulfurtransferases Journal Article Research Support, U.S. Gov't, P.H.S.

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G Tennekoon, C S Aitchison, J Frangia, D L Price, A M Goldberg. 1979. Chronic lead intoxication: effects on developing optic nerve.. https://doi.org/10.1002/ana.410050611

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