Local immune response in endometrial carcinomas.

T Hachisuga; K Fukuda; S Nakamura; T Iwasaka; H Sugimori

doi:10.1111/j.1471-0528.1997.tb10660.x

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Local immune response in endometrial carcinomas.

T Hachisuga·K Fukuda·S Nakamura·T Iwasaka·H Sugimori

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Abstract

OBJECTIVE: To determine whether Langerhans cells act as antigen-presenting cells in endometrial carcinomas and their related lesions. SAMPLES: Frozen endometrial samples were obtained from 13 women with normal menstrual cycles, 3 postmenopausal women, 11 women with hyperplasia (simple 4, complex 4 and atypical 3) and 32 women with endometrial carcinomas. MAIN OUTCOME MEASURES: Langerhans cells (CD1), T lymphocytes (CD4 and CD8), B lymphocytes (CD22), natural killer (NK) cells (CD57) and HLA-DR were all quantitatively assessed in endometrial samples using immunohistochemical method. RESULTS: The numbers of Langerhans, CD4+, CD8+ and B cells were higher in the secretory phase than in the proliferative endometrium. The CD8+ cells appeared to be more plentiful than the CD4+ cells. When compared with the proliferative endometrium, the numbers of Langerhans cells were higher in hyperplasias and carcinomas. Most of Langerhans cells were HLA-DR+, showing a strong correlation with CD4+ cells in carcinomas. This suggests that MHC class II antigen restricted lymphocytes in carcinomas are activated by HLA-DR+ Langerhans cells. However, epithelial expression of HLA-DR in carcinomas did not show on association with high numbers of Langerhans and CD4+ cells. No correlation was observed between Langerhans cells and clinicopathologic features of carcinomas. In contrast, the number of NK cells significantly decreased in noninvasive carcinomas but increased in Grade 3 tumours. CONCLUSION: Based on the above findings, Langerhans cells are considered to act as antigen-presenting cells in carcinomas, but it was not shown that they were activated by epithelial expression of HLA-DR in carcinomas.

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B-Lymphocytes CD4 Antigens CD4-CD8 Ratio CD8 Antigens Endometrial Hyperplasia Endometrial Neoplasms Female Humans Immunohistochemistry Killer Cells, Natural Langerhans Cells T-Lymphocytes Journal Article

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T Hachisuga, K Fukuda, S Nakamura, T Iwasaka, H Sugimori. 1997. Local immune response in endometrial carcinomas.. https://doi.org/10.1111/j.1471-0528.1997.tb10660.x

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