Calcineurin-immunosuppressor complexes.

B L Stoddard; K E Flick

doi:10.1016/s0959-440x(96)80006-6

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PubMed · 8994877

Calcineurin-immunosuppressor complexes.

B L Stoddard·K E Flick

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Abstract

Crystal structures of the Ser/Thr phosphatase calcineurin (protein phosphatase 2B) have recently been solved by X-ray crystallography, both in the free-protein state, and complexed with the immunophilin/immunosuppressant FKBP12/FK506. Core elements of the calcineurin phosphatase have been found to be similar to the corresponding elements of Ser/Thr phosphatase 1 and purple acid phosphatase. The structures provide a basis for understanding calcineurin inhibition by a ternary complex of immunophilin and immunosuppressant proteins.

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Binding Sites Calcineurin Calmodulin-Binding Proteins Carrier Proteins Crystallography, X-Ray DNA-Binding Proteins Heat-Shock Proteins Immunosuppressive Agents Models, Molecular Phosphoprotein Phosphatases Protein Conformation Protein Phosphatase 1 Protein Structure, Secondary Tacrolimus Binding Proteins Journal Article Review

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B L Stoddard, K E Flick. 1996. Calcineurin-immunosuppressor complexes.. https://doi.org/10.1016/s0959-440x(96)80006-6

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