p53 Phosphorylation: biochemical and functional consequences.

G J Milczarek; J Martinez; G T Bowden

doi:10.1016/s0024-3205(96)00479-1

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p53 Phosphorylation: biochemical and functional consequences.

G J Milczarek·J Martinez·G T Bowden

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Abstract

The p53 protein plays a vital role in suppressing the development of cancer. Posttranslational modification through phosphorylation has been postulated to be an important regulatory mechanism of p53 function. Data describing the role of phosphorylation in terms of its effects on several biochemical properties and cellular functions of p53 are examined in the context of how p53 might be "phospho-regulated."

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Animals Cell Division Cell Transformation, Viral DNA DNA Replication Humans Phosphoprotein Phosphatases Phosphorylation Protein Conformation Protein Kinases Transcription, Genetic Tumor Cells, Cultured Tumor Suppressor Protein p53 Journal Article Review

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G J Milczarek, J Martinez, G T Bowden. 1997. p53 Phosphorylation: biochemical and functional consequences.. https://doi.org/10.1016/s0024-3205(96)00479-1

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