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PubMed · 8996403

Renal cryotherapy in a sheep model; a feasibility study.

P J Cozzi·W J Lynch·S Collins·L Vonthethoff·D L Morris
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Abstract

PURPOSE: This study was designed to evaluate the safety and efficacy of renal cryotherapy as a possible treatment of renal malignancy with preservation of renal parenchyma. MATERIALS AND METHODS: Ten Merino sheep were anaesthetised and the right kidney was exposed through a retro-peritoneal approach. A 5 mm. cryotherapy probe (LCS 3000 Cryotec UK) was inserted into the lower pole of the kidney and freezing was undertaken to form an iceball 5 cm. in diameter. RESULTS: There was no mortality and no complications were observed. A transient rise in creatinine was observed post-operatively. The sheep were euthenased at 4 weeks and at necropsy macroscopic examination revealed a contracted, fibrotic wedge shaped lesion of 3 cm in diameter. Histological examination of the "cryolesion" revealed a central area of coagulative necrosis and a 5 mm rim of partial necrosis with preservation of renal tubules. CONCLUSION: We conclude that renal cryotherapy is safe and can achieve effective renal necrosis in the sheep model.

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AnimalsCryosurgeryEvaluation Studies as TopicFeasibility StudiesKidney NeoplasmsSheepJournal Article

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P J Cozzi, W J Lynch, S Collins, L Vonthethoff, D L Morris. 1997. Renal cryotherapy in a sheep model; a feasibility study.. https://pubmed.ncbi.nlm.nih.gov/8996403/

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