E-state fields: applications to 3D QSAR.

G E Kellogg; L B Kier; P Gaillard; L H Hall

doi:10.1007/bf00134175

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E-state fields: applications to 3D QSAR.

G E Kellogg·L B Kier·P Gaillard·L H Hall

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Abstract

The derivation of a new 3D QSAR field based on the electrotopological state (E-state) formalism is described. A complementary index and its associated field, the HE-state, describing the polarity of hydrogens is also defined. These new fields are constructed from a nonempirical index that incorporates electronegativity, the inductive influence of neighboring atoms, and the topological state into a single atomistic descriptor. The classic CoMFA steroid test data set was examined with models incorporating the E-state and HE-state fields alone and in combination with steric, electrostatic and hydropathic fields. The single best model was the E-state/HE-state combination with q2 = 0.803 (three components) and r2 = 0.979. Using the E-state and/or HE-state fields with other fields consistently produced models with improved statistics, where the E-state fields provided a significant, if not dominant, contribution.

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Binding Sites Computer-Aided Design Drug Design Electrochemistry Hydrogen Models, Molecular Receptors, Steroid Steroids Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't

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G E Kellogg, L B Kier, P Gaillard, L H Hall. 1996. E-state fields: applications to 3D QSAR.. https://doi.org/10.1007/bf00134175

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