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PubMed · 900906

Peripheral nerve abnormality in multiple sclerosis.

M Pollock·C Calder·S Allpress
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Abstract

Biopsy specimens of sural nerve from 10 patients with multiple sclerosis (MS), of whom only 1 was severely disabled, were assessed by morphometric techniques and compared to nerves from age-matched controls. The frequency of abnormal teased fibers was increased in MS nerve, with many internodes showing at least a 50% reduction in myelin thickness. Myelinated nerve fiber densities were not significantly different in MS and control nerves. Regression analysis of axonal area on number of myelin lamellae indicated a generalized reduction of myelin lamellae in this disorder. It is suggested that peripheral myelin may be involved in multiple sclerosis.

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AxonsHumansMultiple SclerosisMyelin SheathPeripheral NervesSchwann CellsSural NerveJournal Article

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M Pollock, C Calder, S Allpress. 1977. Peripheral nerve abnormality in multiple sclerosis.. https://doi.org/10.1002/ana.410020107

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