Negative selection in the thymus includes semimature T cells.

H Kishimoto; J Sprent

doi:10.1084/jem.185.2.263

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PubMed · 9016875

Negative selection in the thymus includes semimature T cells.

H Kishimoto·J Sprent

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Abstract

The thymic medulla plays a key role in negative selection (self-tolerance induction) and contains differentiated T cells en route to the extrathymic environment. However, being relatively mature, medullary T cells are thought to be beyond the stage of tolerance induction. This paradox is resolved by the finding that medullary T cells (CD4+8- thymocytes) comprise two distinct subsets. Medullary thymocytes expressing a fully mature (HSAlo) phenotype are strongly resistant to tolerance induction, whereas cells with a semimature (HSAhi) phenotype are tolerance susceptible. These findings suggest that the differentiated T cells reaching the medulla from the cortex remain sensitive to tolerance induction for a brief period before acquiring a fully mature tolerance-resistant phenotype. The semimature subset of medullarsy T cells displays unique requirements for tolerance induction; depending upon the conditions used, tolerizing these cells can involve either a Fas (CD95)-dependent or a Fas-independent pathway.

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Animals CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Mice Mice, Inbred Strains Receptors, Antigen, T-Cell T-Lymphocyte Subsets Thymus Gland Journal Article Research Support, U.S. Gov't, P.H.S.

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H Kishimoto, J Sprent. 1997-01-20. Negative selection in the thymus includes semimature T cells.. https://doi.org/10.1084/jem.185.2.263

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