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PubMed · 902434

Normal values for serum dopamine-beta-hydroxylase activity.

K Fujita·K Maruta·R Teradaira·H Beppu·M Ikegame·T Nagatsu·T Kato
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K Fujita, K Maruta, R Teradaira, H Beppu, M Ikegame, T Nagatsu, T Kato. 1977. Normal values for serum dopamine-beta-hydroxylase activity.. https://pubmed.ncbi.nlm.nih.gov/902434/

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PubMed2003

No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia.

OBJECTIVE: Disturbances in catecholamine transmission have been implicated in schizophrenia. Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells. We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for association with schizophrenia. METHODS: Unrelated schizophrenic patients (n=155) and control subjects (n=436) were analysed with regard to the DBH -1021 C/T variant. RESULTS: No significant allele or genotype differences were found. CONCLUSIONS: The present results do not support a major involvement of the DBH gene in schizophrenia in the Swedish population investigated.

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