DCC's function takes shape in the nervous system.

P A Kolodziej

doi:10.1016/s0959-437x(97)80114-1

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PubMed · 9024638

DCC's function takes shape in the nervous system.

P A Kolodziej

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Abstract

Deleted in colorectal cancer (DCC), a candidate tumor-suppressor gene, has recently been found to encode a netrin receptor required for axon guidance in vitro. Mutations in Caenorhabditis elegans and Drosophila genes encoding DCC-related proteins affect axon guidance, and these phenotypes resemble those of mutations in netrin genes. Netrins and their DCC-related receptors thus play an evolutionarily conserved role in midline guidance, and DCC may be required more generally for cellular morphogenesis.

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Amino Acid Sequence Animals Axons Cell Adhesion Molecules DCC Receptor Genes, DCC Humans Molecular Sequence Data Nervous System Physiological Phenomena Receptors, Cell Surface Tumor Suppressor Proteins Journal Article Review

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P A Kolodziej. 1997. DCC's function takes shape in the nervous system.. https://doi.org/10.1016/s0959-437x(97)80114-1

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