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Staphylococcal nuclease reviewed: a prototypic study in contemporary enzymology. IV. The nuclease as a model for protein folding.

P W Tucker·E E Hazen·F A Cotton
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Abstract

This is the last in a series of four articles in which the chemical, enzymological and crystallographic work on Ribonucleate (deoxyribonucleate)-3'-nucleotidohydrolase, EC 3.1.4.4 (staphylococcal nuclease, micrococcal nuclease) will be reviewed and correlated. This article discusses the use of the nuclease as a model system for the study of the mechanisms and energetics of the folding-unfolding reaction in proteins and for the study of the interrelationships between amino acid sequence and three-dimensional structure.

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EpitopesHydrogen-Ion ConcentrationKineticsLigandsMicrococcal NucleaseModels, ChemicalPeptide FragmentsProtein ConformationProtein DenaturationThermodynamicsJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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P W Tucker, E E Hazen, F A Cotton. 1979-02-09. Staphylococcal nuclease reviewed: a prototypic study in contemporary enzymology. IV. The nuclease as a model for protein folding.. https://doi.org/10.1007/bf00219452

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PubMed1979

Factor VIII: new clinical and genetic aspects.

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