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A new method for analyzing protein sequence relationships based on Sammon maps.

D K Agrafiotis
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Abstract

Recent advances in gene sequencing and rational drug design have re-emphasized the need for new methods for protein analysis, classification, and structure and function prediction. In this article, we introduce a new method for analyzing protein sequences based on Sammon's non-linear mapping algorithm. When applied to a family of homologous sequences, the method is able to capture the essential features of the similarity matrix, and provides a faithful representation of chemical or evolutionary distance in a simple and intuitive way. The merits of the new algorithm are demonstrated using examples from the protein kinase family.

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BibTeXRIS

D K Agrafiotis. 1997. A new method for analyzing protein sequence relationships based on Sammon maps.. https://doi.org/10.1002/pro.5560060203

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