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Functional dose-volume histograms for functionally heterogeneous normal organs.

Y Lu·D R Spelbring·G T Chen
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Abstract

Functional dose-volume histograms are proposed as an extension of the conventional dose-volume histograms, for quantitative assessment of three-dimensional radiation dose coverage of functionally heterogeneous normal organs. Examples are given to illustrate possible applications of this approach to the treatment of a brain tumour or a lung tumour, in which cases the distribution of the normal organ function can be obtained from functional dose-volume modalities. It is shown that a significant difference exists between the functional dose-volume histograms and the conventional dose-volume histograms when the normal organ function is non-uniformly distributed within the organ. Utilization of functional dose-volume histograms as the input for the calculation of normal tissue complication probabilities is discussed for different normal tissue structures.

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HumansLung NeoplasmsMagnetic Resonance ImagingModels, TheoreticalNeoplasmsPhantoms, ImagingRadiation DosageRadiotherapy DosageRadiotherapy Planning, Computer-AssistedTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonJournal Article

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Y Lu, D R Spelbring, G T Chen. 1997. Functional dose-volume histograms for functionally heterogeneous normal organs.. https://doi.org/10.1088/0031-9155%2F42%2F2%2F007

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