Synaptic innervation density is regulated by neuron-derived BDNF.

C G Causing; A Gloster; R Aloyz; S X Bamji; E Chang; J Fawcett; G Kuchel; F D Miller

doi:10.1016/s0896-6273(00)80266-4

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Synaptic innervation density is regulated by neuron-derived BDNF.

C G Causing·A Gloster·R Aloyz·S X Bamji·E Chang·J Fawcett·G Kuchel·F D Miller

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Abstract

In this report, we have examined the role of neuron-derived BDNF at an accessible synapse, that of preganglionic neurons onto their sympathetic neuron targets. Developing and mature sympathetic neurons synthesize BDNF, and preganglionic neurons express the full-length BDNF/TrkB receptor. When sympathetic neuron-derived BDNF is increased 2- to 4-fold in transgenic mice, preganglionic cell bodies and axons hypertrophy, and the synaptic innervation to sympathetic neurons is increased. Conversely, when BDNF synthesis is eliminated in BDNF -/- mice, preganglionic synaptic innervation to sympathetic neurons is decreased. Together these results indicate that variations in neuronal neurotrophin synthesis directly regulate neuronal circuitry by selectively modulating synaptic innervation density.

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Animals Axons Brain-Derived Neurotrophic Factor Dopamine beta-Hydroxylase Fluorescent Antibody Technique, Indirect Gene Expression Mice Mice, Knockout Mice, Transgenic Microscopy, Electron Nerve Fibers, Myelinated Superior Cervical Ganglion Sympathetic Nervous System Synapses Synapsins Journal Article Research Support, Non-U.S. Gov't

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C G Causing, A Gloster, R Aloyz, S X Bamji, E Chang, J Fawcett, G Kuchel, F D Miller. 1997. Synaptic innervation density is regulated by neuron-derived BDNF.. https://doi.org/10.1016/s0896-6273(00)80266-4

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