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PAX-6 in development and evolution.

P Callaerts·G Halder·W J Gehring
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Abstract

Pax-6 is a member of the Pax gene class and encodes a protein containing a paired domain and a homeodomain. The molecular characterization of Pax-6 genes from species of different animal phyla and the analysis of Pax-6 function in the developing eyes and central nervous system of vertebrates, Drosophila melanogaster, and Caenorhabditis elegans suggest that Pax-6 homologues share conserved functions. In this review, we present recent data on the structural and functional characterization of Pax-6 homologues from species of different animal phyla. We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems.

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AnimalsBiological EvolutionDNA-Binding ProteinsEye ProteinsHomeodomain ProteinsPAX6 Transcription FactorPaired Box Transcription FactorsRepressor ProteinsTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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P Callaerts, G Halder, W J Gehring. 1997. PAX-6 in development and evolution.. https://doi.org/10.1146/annurev.neuro.20.1.483

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