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PubMed · 9061843

Selecting the best dose when a monotonic dose-response relation exists.

E Russek-Cohen·R M Simon
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Abstract

We propose a method for selecting the best treatment when a monotonic dose-response relationship exists. Because of side effects associated with higher doses, the highest dose may not be the optimum, particularly when a lower dose gives a similar response. Rather than assume a particular functional relationship of dose to response, we use isotonic regression techniques. We consider the case of three treatment levels, which is applicable to many clinical trials. The lowest treatment level may represent a placebo or no treatment control. While we focus primarily on Bernoulli response variables, we also discuss a model for normally distributed data. We suggest a two-stage procedure that we have investigated via simulation.

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Clinical Trials, Phase II as TopicDecision Support TechniquesDose-Response Relationship, DrugDrug EvaluationHumansModels, StatisticalRegression AnalysisResearch DesignSample SizeSurvival AnalysisZidovudineJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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E Russek-Cohen, R M Simon. 1994-01-15. Selecting the best dose when a monotonic dose-response relation exists.. https://doi.org/10.1002/sim.4780130110

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