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PubMed · 9063086

Quantitative structure-activity relationship (QSAR) study of polyhydroxyxanthones.

J Ungwitayatorn·M Pickert·A W Frahm
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Abstract

In the present study 13C-chemical shift additivity rules are developed for polyhydroxyxanthones with antituberculotic activity against Mycobacterium tuberculosis. QSAR investigations are performed by correlating 13C-chemical shifts and calculated dipole moments of several 1,3-substituted polyhydroxyxanthones with their antituberculotic activity and by using the CoMFA approach as a three-dimensional QSAR method.

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Antitubercular AgentsCarbon IsotopesMagnetic Resonance SpectroscopyStructure-Activity RelationshipXanthenesJournal ArticleResearch Support, Non-U.S. Gov't

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J Ungwitayatorn, M Pickert, A W Frahm. 1997. Quantitative structure-activity relationship (QSAR) study of polyhydroxyxanthones.. https://doi.org/10.1016/s0031-6865(96)00043-x

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