PubMed Health⌕ Search

PubMed · 9063534

Soft tissues sarcoma with acute paraneoplastic hepatic dysfunction: case report.

Abstract

A case of malignant fibrous histiocytoma of soft tissues of the right scapula associated with transitory hepatic dysfunction in the absence of liver metastases is reported. After primary radiation therapy, the patient manifested fever, anemia, thrombocytosis and hepatic dysfunction. All the abnormalities disappeared immediately after complete removal of the tumor. The patient was well, with no evidence of distant metastases, at more than 12 months later. It is concluded that the abnormalities of laboratory data were indirectly induced by the tumor, although the exact mechanism of this paraneoplastic syndrome was not clarified.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

G Bisagni, C Boni, G Fornaciari, F Gherlinzoni. Soft tissues sarcoma with acute paraneoplastic hepatic dysfunction: case report.. https://doi.org/10.1177/030089169608200520

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Primary malignant fibrous histiocytoma extending into spinal canal through intervertebral foramina.

A 60-year-old man was referred to us because of gradual-onset radiculopathy in his left leg for 2 months. Magnetic Resonance Imaging (MRI) of the lumbar spine demonstrated a relatively homogeneous huge mass in the left paravertebral area from L1 to L3 (Fig. 1A, B). Axial MRI scan (Fig. 1C) confirmed the extension of the tumour into the adjacent spinal canal through the neural foramina, forming an extradural mass, which resulted in the compression of both the dural sac and the nerve roots. The patient was operated on by a staged-resection. First, a left retroperitoneal approach was performed for the paraspinal mass. The tumour appeared brown to tan in color and was moderately firm. Nine days after his first operation, the patient underwent a resection of the intraspinal/extradural tumour by a posterior approach. After the left L1-2 hemilaminectomy was performed, the extradural tumour was easily identified, dissected, and completely removed. Microscopically, it was a highly cellular tumour composed of anaplastic cells assuming a gigantic size with bizarre nuclei, which were admixed with inflammatory cells (Fig. 1D). The tumour cells were immunohistochemically characterized by positive staining for vimentin confirming its mesenchymal origin, and CD68 consistent with histiocyte-like qualities (Fig. 1E, F). A diagnosis of inflammatory malignant fibrous histiocytoma (MFH) could be made. Postoperatively, the patient made an uneventful recovery and received radiotherapy as an adjuvant therapy.

Histiocytoma, Benign Fibrous↗