PubMed HealthSearch

PubMed · 906410

[Tumor angiogenesis factor and its possible utilization].

Abstract

A brief survey of the literature data on tumor angiogenic factor stimulating intratumor growth of new vessels is given. Under consideration is the possibility to use inhibitors of the factor, in particular antibodies against it, to suppress tumor growth. Also, it is suggested to use tumor angiogenic factor for revascularization of infarction and ischemic tissues, especially in myocardial ischemia.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

G Ia Svet-Moldavskiĭ. 1977. [Tumor angiogenesis factor and its possible utilization].. https://pubmed.ncbi.nlm.nih.gov/906410/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Angiogenic effects of macrophages isolated from ascitic fluid aspirated from women with advanced ovarian cancer.

The cellular components of ascitic fluid aspirated from the peritoneal cavity of women with advanced ovarian cancer were separated on a Ficoll gradient. Isolated macrophages, which were further purified, elaborated a growth factor which was mitogenic for human endothelial cells isolated from umbilical veins, arteries and the omental microvasculature in vitro, and was angiogenic in vivo. It is postulated that the macrophage-derived factor enhances tumor neovascularization of the widespread ovarian-derived peritoneal malignant lesions appearing in these patients, thus contributing to their rapid growth and metastasis, and the poor prognosis of the disease.

Angiogenesis Inducing Agents