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PubMed · 9066762

Targeted screening for elongation factor Tu binding antibiotics.

E Selva·N Montanini·S Stella·A Soffientini·L Gastaldo·M Denaro
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Abstract

The development of a screen targeted to antibiotics which bind elongation factor Tu (EF-Tu) is described. The method was based on selection of antimicrobial activities which were antagonized by exogenous EF-Tu. Kirromycin, a known inhibitor of EF-Tu, was positive in this screen. Among 47,000 microorganisms screened, several producers of kirromycin-type antibiotics were detected and the novel antibiotics GE2270 and GE37468 were discovered. These thiopeptide molecules constitute, along with amithiamycin, a novel class of antibiotics acting on EF-Tu.

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ActinomycetalesAnti-Bacterial AgentsPeptide Elongation Factor TuPyridonesJournal Article

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E Selva, N Montanini, S Stella, A Soffientini, L Gastaldo, M Denaro. 1997. Targeted screening for elongation factor Tu binding antibiotics.. https://doi.org/10.7164/antibiotics.50.22

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