PubMed · 9068878
Rational monotherapy for epilepsy.
Abstract
At the present time monotherapy is preferable to polytherapy if the epilepsy can be controlled with a single drug. However, persons with intractable epilepsy may need more than one antiepileptic drug to attain the best seizure control with the fewest side-effects. Although clinical studies have not been performed to identify the best combinations, rational polytherapy would imply combining antiepileptic drugs with different mechanisms of action.
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I E Leppik. 1996. Rational monotherapy for epilepsy.. https://pubmed.ncbi.nlm.nih.gov/9068878/
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