Immunoisolation: at a turning point.

R P Lanza; W L Chick

doi:10.1016/s0167-5699(97)01008-6

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Immunoisolation: at a turning point.

R P Lanza·W L Chick

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Abstract

The principle of immunoisolation is to separate transplanted cells from the hostile immunological environment of the host by a selectively permeable membrane. Low-molecular-weight substances such as nutrients, electrolytes, oxygen and biotherapeutic agents are exchanged across the membrane, while immunocytes, antibodies and other transplant-rejection effector mechanisms are excluded. Here, Robert Lanza and William Chick review these systems.

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Animals Antibody Formation Diabetes Mellitus, Type 1 Graft Survival Humans Immunologic Techniques Islets of Langerhans Transplantation Membranes, Artificial Transplantation Immunology Transplantation, Heterologous Journal Article Review

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R P Lanza, W L Chick. 1997. Immunoisolation: at a turning point.. https://doi.org/10.1016/s0167-5699(97)01008-6

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