Protein folding from a combinatorial perspective.

R T Sauer

doi:10.1016/s1359-0278(96)00015-6

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Protein folding from a combinatorial perspective.

R T Sauer

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Abstract

Combinatorial mutagenesis experiments show the existence of many different solutions to the problem of complementary packing of non-polar sidechains in the protein core. They suggest that a significant amount of structural information is carried by the simple pattern of polar and non-polar residues along the polypeptide chain, indicate that the formation of buried polar interactions may be a fundamentally slow step in protein folding and show that proteins with many native properties occur at reasonable frequencies in random sequence libraries.

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DNA-Binding Proteins Hydrogen Bonding Molecular Structure Mutagenesis Protein Conformation Protein Folding Proteins Repressor Proteins Viral Proteins Viral Regulatory and Accessory Proteins Journal Article Review

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R T Sauer. 1996. Protein folding from a combinatorial perspective.. https://doi.org/10.1016/s1359-0278(96)00015-6

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