Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice.

A Kirkwood; A Silva; M F Bear

doi:10.1073/pnas.94.7.3380

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Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice.

A Kirkwood·A Silva·M F Bear

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Abstract

Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking alpha-calcium/calmodulin-dependent protein kinase II (alphaCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in alphaCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age.

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Aging Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases Cerebral Cortex Long-Term Potentiation Mice Mice, Mutant Strains Neuronal Plasticity Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

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A Kirkwood, A Silva, M F Bear. 1997-04-01. Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice.. https://doi.org/10.1073/pnas.94.7.3380

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