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PubMed · 9097470

Conductance-based integrate-and-fire models.

A Destexhe
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Abstract

A conductance-based model of Na+ and K+ currents underlying action potential generation is introduced by simplifying the quantitative model of Hodgkin and Huxley (HH). If the time course of rate constants can be approximated by a pulse, HH equations can be solved analytically. Pulse-based (PB) models generate action potentials very similar to the HH model but are computationally faster. Unlike the classical integrate-and-fire (IAF) approach, they take into account the changes of conductances during and after the spike, which have a determinant influence in shaping neuronal responses. Similarities and differences among PB, IAF, and HH models are illustrated for three cases: high-frequency repetitive firing, spike timing following random synaptic inputs, and network behavior in the presence of intrinsic currents.

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Action PotentialsComputer SimulationElectrophysiologyIon ChannelsMembrane PotentialsNeural Networks, ComputerPotassium ChannelsSodium ChannelsJournal ArticleResearch Support, Non-U.S. Gov't

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A Destexhe. 1997-04-01. Conductance-based integrate-and-fire models.. https://doi.org/10.1162/neco.1997.9.3.503

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