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B cell development and differentiation.

P D Burrows·M D Cooper
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Abstract

The initial phases of B cell development depend on interactions between the cell surface molecules and secreted products of stromal cells with their receptor-ligand partners on lymphoid progenitors. Recent research in this area has greatly advanced our understanding of B cell development and differentiation. Antigen receptors on pre-B and B cells play key roles in the progression of this differentiation process, as revealed by targeted and inherited gene mutations that disrupt B cell development and by the transgenic repair of these mutations in mice.

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AnimalsB-LymphocytesCell DifferentiationHumansLeukopoiesisMiceJournal ArticleReview

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P D Burrows, M D Cooper. 1997. B cell development and differentiation.. https://doi.org/10.1016/s0952-7915(97)80142-2

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