PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 9105267

Capillary electrophoresis system for hemoglobin A1c determinations evaluated.

C J Doelman·C W Siebelder·W A Nijhof·C W Weykamp·J Janssens·T J Penders
View original source ↗Export metadata ↓

Abstract

Hb A1c is the analyte of choice for monitoring metabolic control in patients with diabetes mellitus. Here we present a new analytical technique for measuring Hb A1c, capillary electrophoresis. The Hb A1c determination is not influenced by the labile Hb A1c fraction or by carbamylated or acetylated hemoglobin derivatives. Also, hemoglobin variants (Hb F, Hb S, and Hb C) do not interfere. This new application of capillary electrophoresis seems to be a valuable analytical tool for measuring Hb A1c in the clinical laboratory.

Explore related subjects

Blood Protein ElectrophoresisDiabetes MellitusElectrophoresis, CapillaryGlycated HemoglobinHumansReproducibility of ResultsSensitivity and SpecificityJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

C J Doelman, C W Siebelder, W A Nijhof, C W Weykamp, J Janssens, T J Penders. 1997. Capillary electrophoresis system for hemoglobin A1c determinations evaluated.. https://pubmed.ncbi.nlm.nih.gov/9105267/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2006

[Monoclonal gammopathies of undetermined significance].

Monoclonal gammopathies of undetermined significance constitute a body of asymptomatic diseases characterized by a selective increase of a single serum immunoglobulin due to an only dysregulated clone of B lymphocytes. They occur in up to 10% of persons over 80 years of age. The diagnosis is suggested in presence of both M component in serum <30 g/L and bone marrow plasma cells <10% by the exclusion of multiple myeloma or lymphoproliferative disorders. In most MGUS, however, populations of normal and myelomatous plasma cells coexist in a stable ratio. The overall relative risk for progression is 7 times the expected rate, depending from the disease and the type of M component.

Blood Protein Electrophoresis↗
PubMed2006

[A rare cause of diffuse pulmonary hemorrhage in a 45 year-old man].

Diffuse pulmonary hemorrhage denotes a diffuse bleeding into the alveoli as a result of severe damage of the alveolocapillary membrane. Autoimmune diseases, toxic injury and hemodynamic changes are the most frequent causes. A 45 year old male patient presented with diffuse alveolar hemorrhage. An Immunoglobulin A (IgA) paraprotein secreting myeloma was found to be the underlying cause. Immunohistochemistry revealed dense pericapillary and perivascular deposits of IgA, indicating a paraprotein mediated damage of the alveolocapillary membrane. The predominantly vascular pattern of damage was regarded as the most likely cause of the pulmonary hypertension in this patient. The diffuse pulmonary bleeding stopped after initiation of treatment consisting of vincristine, adriamycine and dexamethasone.

Blood Protein Electrophoresis↗