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Decrease in cerebral free magnesium concentration following closed head injury and effects of VA-045 in rats.

M Suzuki·M Nishina·M Endo·K Matsushita·M Tetsuka·K Shima·S Okuyama
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Abstract

1. We examined the alterations in cerebral free Mg2+ concentration in closed head injury (CHI) in rats and the effects of VA-045, a novel apovincaminic acid derivative, on them with in vivo 31P-NMR. 2. Free Mg2+ decreased by about 30% within 20 min after head impact and, afterward, it gradually decreased further to reach about 60% of the control level after 3 hr. VA-045 inhibited the decrease. 3. In nonimpacted rats, VA-045 did not alter the free Mg2+ level. 4. The decrease in cerebral free Mg2+ following CHI may be a critical factor in the development of irreversible tissue injury, and VA-045 may prevent it.

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AnimalsBrain ChemistryHead Injuries, ClosedHydrogen-Ion ConcentrationMagnesiumMagnetic Resonance SpectroscopyMaleRatsRats, WistarJournal Article

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M Suzuki, M Nishina, M Endo, K Matsushita, M Tetsuka, K Shima, S Okuyama. 1997. Decrease in cerebral free magnesium concentration following closed head injury and effects of VA-045 in rats.. https://doi.org/10.1016/s0306-3623(96)00148-6

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