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PubMed · 9112168

Genetic markers in primary open-angle glaucoma.

E Abecia·B Martínez-Jarreta·Y Casalod·B Bell·I Pinilla·F M Honrubia
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Abstract

PURPOSE: To investigate possible associations between genetic markers and Primary Open-Angle Glaucoma (POAG). METHODS: A number of genetic markers were typed in 84 unrelated patients with POAG and compared with a random sample of healthy individuals. The markers were Transferrin, Group Specific Component, G1m (1), G1m (2) and G3m (5) Allotypes, Adenylate Kinase, Adenosin Deaminase, Glyoxalase I and Acid Phosphatase and PCR-based markers HLA-DQA1 and D1S80. RESULTS: No significant differences were found except the strong association between the group of POAG patients and Acid Phosphatase ACP*C allele (chi 2 = 32.86; p < 0.0001). CONCLUSIONS: Since Acid Phosphatase gene is localized to chromosome 2p23, this result could be a first comprehensive step in the localization of POAG genes.

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Acid PhosphataseAdenosine DeaminaseAdenylate KinaseDNADNA PrimersElectrophoresis, Polyacrylamide GelGene FrequencyGenetic MarkersGlaucoma, Open-AngleHLA-DQ AntigensHLA-DQ alpha-ChainsHumansImmunoglobulin Gm AllotypesLactoylglutathione LyasePolymerase Chain ReactionPolymorphism, GeneticRisk FactorsTransferrinVitamin D-Binding ProteinJournal Article

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E Abecia, B Martínez-Jarreta, Y Casalod, B Bell, I Pinilla, F M Honrubia. Genetic markers in primary open-angle glaucoma.. https://doi.org/10.1007/bf00212950

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