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Ras-GTPase activating protein (GAP): a putative effector for Ras.

B Tocque·I Delumeau·F Parker·F Maurier·M C Multon·F Schweighoffer
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Abstract

One attractive candidate for a Ras effector protein, other than the Raf kinases, is Ras-GAP. Indeed, recent literature suggests that besides the Raf/MAP kinase cascade, additional pathways must be stimulated to elicit a full biological response to Ras. Ras binds the COOH terminal domain of Ras-GAP, while the NH2 terminal domain appears to be essential for triggering downstream signals. Since Ras-GAP itself has no obvious enzymatic function that might explain a role in processes associated with proliferation, differentiation or apoptosis, candidates for downstream Ras-GAP effectors that fulfill this role remain to be identified. The newly found GAP-SH3 domain Binding Protein (G3BP) may be one of these. This review will briefly overview the candidates Ras effectors and discuss the results that position Ras-GAP as a critical effector downstream of Ras.

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AnimalsGTPase-Activating ProteinsHumansProteinsSignal Transductionras GTPase-Activating Proteinsras ProteinsJournal ArticleReview

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B Tocque, I Delumeau, F Parker, F Maurier, M C Multon, F Schweighoffer. 1997. Ras-GTPase activating protein (GAP): a putative effector for Ras.. https://doi.org/10.1016/s0898-6568(96)00135-0

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