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PubMed · 9115425

Deconstructing the nucleus: global architecture from local interactions.

W F Marshall·J C Fung·J W Sedat
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Abstract

Recent advances in fluorescence in situ hybridization and three-dimensional microscopy have revealed a high degree of large-scale order in the nucleus, indicating that the position of each gene within the nucleus is not random. As with any other biological phenomenon, this large-scale organization must ultimately be specified by molecular interactions. Biochemical and molecular investigations have revealed a small set of local molecular-scale interactions that can be used together in a combinatorial fashion to establish a global large-scale nuclear architecture.

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W F Marshall, J C Fung, J W Sedat. 1997. Deconstructing the nucleus: global architecture from local interactions.. https://doi.org/10.1016/s0959-437x(97)80136-0

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