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A two-backbone polymer model for interphase chromosome geometry.

B Liu·R K Sachs
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Abstract

A polymer model for the overall geometric structure of a human chromosome during the G0/G1 portion of cell-cycle interphase is constructed, based on fluorescence in situ hybridization data on distances between defined genomic sequences. The model consists of flexible giant loops, averaging about 6 million base pairs, with two random-walk backbones; it involves essentially three parameters. Numerical results based on properly selected values of parameters fit the data well.

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Chromosomes, HumanHumansIn Situ Hybridization, FluorescenceInterphaseMathematicsModels, GeneticPolymersJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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B Liu, R K Sachs. 1997. A two-backbone polymer model for interphase chromosome geometry.. https://doi.org/10.1007/bf02462006

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