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Transforming growth factor-beta localization during mouse prostate morphogenesis and in prostatic growth abnormalities.

T L Timme·G Yang·L D Truong·D Kadmon·S H Park·T C Thompson
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Abstract

Growth and morphogenesis of the prostate involves mesenchymal-epithelial interactions. Transforming growth factor-beta 1 (TGF-beta1) is one growth factor that may play a role in these paracrine interactions. We have localized TGF-beta1 by molecular and immunohistochemical analysis in the developing mouse prostate. Accumulations of TGF-beta1 protein were localized in the mesenchyme surrounding ductules in fetal and neonatal prostate. Previous studies in the mouse prostate reconstitution (MPR) model system have localized accumulations of TGF-beta1 to regions of oncogene-induced abnormalities. In surgically excised adult human prostate tissues, localized accumulations of TGF-beta1 are associated with prostate cancer and benign prostatic hyperplasia (BPH). Intracellular TGF-beta1 was more often associated with stromal cells in BPH and with neoplastic epithelial cells in prostate cancer. The production and accumulation of TGF-beta1 appears to involve interactions between mesenchymal and epithelial cells. Further experimental studies may clarify the relationships between TGF-beta1 and abnormal prostatic growth.

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AnimalsEmbryonic and Fetal DevelopmentHumansImmunohistochemistryMaleMiceProstateProstatic HyperplasiaProstatic NeoplasmsTransforming Growth Factor betaJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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T L Timme, G Yang, L D Truong, D Kadmon, S H Park, T C Thompson. 1995. Transforming growth factor-beta localization during mouse prostate morphogenesis and in prostatic growth abnormalities.. https://doi.org/10.1007/bf00191212

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