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Zero interaction response surfaces for combined-action assessment.

J Sühnel
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Abstract

Combined-action assessment requires first the calculation of combination effects expected for the case of no interaction. In a second step the experimental combination effects have to be compared to the expected ones in order to classify the combination as synergistic or antagonistic. Adopting the response surface methodology, a new procedure for the calculation of zero interaction response surfaces which can be applied both to various criteria for defining zero interaction and to various types of dose-response relations is proposed. The approach requires only information from single-agent dose-response relations, but provides nevertheless a comprehensive overview over the complete dose range under study. It can replace the tedious isobolographic analysis if the dose-additivity criterion is adopted.

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Dose-Response Relationship, DrugDrug InteractionsDrug SynergismHazardous SubstancesModels, ChemicalRegression AnalysisJournal Article

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J Sühnel. Zero interaction response surfaces for combined-action assessment.. https://doi.org/10.1016/s0278-6915(97)00087-2

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