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PubMed · 9122584

Force, development, and neoplasia: development from another perspective as illustrated through a study of in vitro plant development from neoplasm.

M M Lieber
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Abstract

Differentiation from the neoplastic state can be a dynamic adaptation to the localized stress of increasing cohesive forces in tissue. Repulsive forces, occurring within and between cells, are seen as leading to de-differentiation into the neoplastic state or neoplasm. During early development, especially where and when mitosis occurs frequently, cohesive and repulsive forces may necessarily coexist in oscillating degrees. Correspondingly, cohesive-force and repulsive-force generating metabolites may co-exist in oscillating concentrations. Cancer or neoplasia occurs, according A. Szent-Gyorgyi, when cohesiveness breaks down locally, probably thru the conversion of methylglyoxal into lactic acid. Cancer may also occur due to the accumulation of such putatively, repulsion-generating factors as lactic acid. Plant tumors in vitro respond adaptively to cohesion-generating chemicals, such as ascorbic acid and methylglyoxal, by generating buds, embryos, and plantlets.

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Adaptation, PhysiologicalAnimalsAscorbic AcidBiological EvolutionCulture MediaCulture TechniquesEmbryonic and Fetal DevelopmentFabaceaeHumansLactic AcidMammalsMiceMutagenesisNeoplasmsPlant DevelopmentPlant TumorsPlantsPlants, MedicinalPlants, ToxicPyruvaldehydeTemperatureTime FactorsNicotianaComparative StudyJournal Article

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M M Lieber. 1996. Force, development, and neoplasia: development from another perspective as illustrated through a study of in vitro plant development from neoplasm.. https://pubmed.ncbi.nlm.nih.gov/9122584/

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