Aging and protein oxidative damage.

S Agarwal; R S Sohal

doi:10.1016/0047-6374(94)90024-8

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PubMed · 9128750

Aging and protein oxidative damage.

S Agarwal·R S Sohal

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Abstract

The hypothesis that aging is associated with the accumulation of oxidative damage was tested in the adult male housefly by monitoring the loss of membrane protein -SH groups, and activities of glucose-6-phosphate dehydrogenase and alcohol dehydrogenase, the cytosolic enzymes that are particularly susceptible to oxidative damage. Membrane protein -SH content and activities of these enzymes decreased with age and were correlated with the life expectancy or physiological age rather than the chronological age of the flies. Because the experimentally-induced loss of membrane protein -SH groups has a demonstrable deleterious effect on a variety of cellular functions, such damage during aging can be hypothesized to contribute to the physiological attrition associated with senescence.

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Aging Alcohol Dehydrogenase Animals Glucosephosphate Dehydrogenase Houseflies Life Expectancy Male Membrane Proteins Oxidative Stress Sulfhydryl Compounds Journal Article Research Support, U.S. Gov't, P.H.S.

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S Agarwal, R S Sohal. 1994. Aging and protein oxidative damage.. https://doi.org/10.1016/0047-6374(94)90024-8

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