PubMed · 913657
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G A Taran, D P Artemenko, A V Govorukha. [Device for inserting a microelectrode into a nerve cell].. https://pubmed.ncbi.nlm.nih.gov/913657/
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A novel neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP), exhibits sequence homology with vasoactive intestinal polypeptide (VIP) and occurs in the mammalian brain, lung and gut. The distribution of PACAP in ganglionic and aganglionic portions of the large intestine of patients with Hirschsprung's disease was examined by immunohistochemistry and radioimmunoassay. PACAP-immunoreactive nerve fibers were distributed in all layers of the ganglionic and aganglionic segments of the intestine, although they were less numerous in the latter, and PACAP-immunoreactive nerve cell bodies were seen in the ganglionic portion of the intestine. The concentration of immunoreactive PACAP was lower in the aganglionic than in the ganglionic segment of the intestinal wall. PACAP and VIP were found to coexist in both ganglionic and aganglionic segments of the intestine. Apparently, PACAP participates in the regulation of gut motility. The scarcer PACAP innervation of the aganglionic segment may contribute to the defect in intestinal relaxation seen in patients with Hirschsprung's disease.
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Our material consisted of 100 adult skulls and 50 adult half-head sections where the posterior opening of the pterygopalatinate fossa and the position of the pterygopalatinate ganglion were investigated. The report contains the following specifics: 1. Course and contents of the pterygoidal canal as well as the topographical relations of the canal to the sphenoid sinus. 2. Positioning of the axis of the foramen rotundum to the various planes of the head and its contents. 3. Course of the vomerovaginal canal and its contents. 4. Distances of the pterygopalatinate ganglion to important reference points of the head and to the median-sagittal line.