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PubMed · 9140059

MutT-related error avoidance mechanism for DNA synthesis.

M Sekiguchi
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Abstract

Mutator mutants that show an increased frequency of spontaneous mutation have led to the elucidation of the multiple pathways of spontaneous mutagenesis. 8-Oxo-dGTP (8-oxo-7,8-dihydrodeoxyguanosine triphosphate) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. MutT protein of Escherichia coli and related mammalian enzymes specifically degrade 8-oxo-dGTP to 8-oxo-dGMP, thereby preventing occurrence of transversion mutation. The gene encoding the human enzyme, designated MTH1 (for mutT homologue 1), maps to chromosome 7p22. These proteins may be responsible for genomic stability.

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Bacterial ProteinsDNA Repair EnzymesDeoxyguanine NucleotidesEscherichia coliEscherichia coli ProteinsHumansMutagenesisPhosphoric Monoester HydrolasesPyrophosphatasesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

M Sekiguchi. 1996. MutT-related error avoidance mechanism for DNA synthesis.. https://doi.org/10.1046/j.1365-2443.1996.d01-232.x

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